What is Plasmapheresis?
Plasmapheresis (also called plasma exchange or PLEX) is a procedure that removes antibodies and other harmful substances from the blood plasma. Blood is drawn, the plasma (containing harmful antibodies) is separated and discarded, and the remaining blood cells are returned to the body along with replacement fluid (albumin or donor plasma).
When is it Used?
Anti-GBM Disease (Goodpasture's)
Removes antibodies attacking kidney and lung tissue
ANCA Vasculitis
Reduces harmful ANCA antibodies causing kidney inflammation
Transplant Rejection
Removes donor-specific antibodies in antibody-mediated rejection
TTP/HUS
Treats thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
Crescentic GN
Rapidly progressive glomerulonephritis with antibody involvement
Myasthenia Gravis
Removes antibodies affecting neuromuscular junction
The Procedure
A large IV line (central venous catheter) is placed, usually in the neck or groin.
Blood is continuously drawn and passed through a machine that separates plasma.
The plasma is replaced with albumin solution or donor plasma.
The blood cells + replacement fluid are returned to the body.
Each session takes 2-3 hours. Usually 5-7 sessions over 2 weeks.
Possible Side Effects
Plasmapheresis is performed under the supervision of Dr. Rajesh Goel